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Intracellular Distribution of Macrophage Targeting Ferritin–Iron Oxide Nanocomposite
Author(s) -
Uchida Masaki,
Willits Deborah A.,
Muller Karin,
Willis Ann F.,
Jackiw Larissa,
Jutila Mark,
Young Mark J.,
Porter Alexandra E.,
Douglas Trevor
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200801209
Subject(s) - ferritin , intracellular , iron oxide , materials science , iron oxide nanoparticles , macrophage , nanotechnology , nanocomposite , transmission electron microscopy , oxide , dark field microscopy , nanoparticle , biophysics , microscopy , microbiology and biotechnology , biology , biochemistry , optics , physics , metallurgy , in vitro
Intracellular distribution of iron oxide nanoparticles incorporated within a ferritin mutant that displays genetically introduced cell‐targeted peptides (RGD‐4C) on its exterior surface are investigated using scanning transmission electron microscopy with a high‐angle annular dark‐field detector. The particles (indicated by arrows) internalized into macrophages much more effectively than those with noncell‐targeted ferritin.