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Ultra‐Low Energy Threshold for Cancer Photothermal Therapy Using Transferrin‐Conjugated Gold Nanorods
Author(s) -
Li Jing Liang,
Day Daniel,
Gu Min
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800941
Subject(s) - nanorod , photothermal therapy , materials science , conjugated system , femtosecond , transferrin , laser , optoelectronics , nanotechnology , optics , polymer , medicine , composite material , physics
Transferrin‐conjugated gold nanorods are used for efficient targeting, two‐photon imaging, and photothermal therapy of cancer cells under both linearly and circularly polarized femtosecond illuminations. The results show that the effective laser energy threshold for therapy can be reduced to around 10 mJ cm −2 , which is one order of magnitude lower than the medical safety standard level.