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A Class of Cationic Triblock Amphiphilic Oligopeptides as Efficient Gene‐Delivery Vectors
Author(s) -
Seow Wei Yang,
Yang YiYan
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800928
Subject(s) - amphiphile , materials science , oligopeptide , cationic polymerization , gene delivery , class (philosophy) , nanotechnology , gene , polymer chemistry , copolymer , genetic enhancement , peptide , polymer , biochemistry , biology , computer science , composite material , artificial intelligence
A new class of triblock oligopeptides , containing arginine for DNA binding, histidine for intracellular buffering, and hydrophobic residues for enhanced cellular uptake has been designed, with each block offering unique functionalities essential for efficient gene delivery. Together, these materials demonstrate strong DNA binding ability, low cytotoxicity, and significantly higher in vivo gene‐transfection efficiency compared to the PEI standard.