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Bioinspired Surface Immobilization of Hyaluronic Acid on Monodisperse Magnetite Nanocrystals for Targeted Cancer Imaging
Author(s) -
Lee Yuhan,
Lee Haeshin,
Kim Young Beom,
Kim Jaeyoon,
Hyeon Taeghwan,
Park HyunWook,
Messersmith Phillip B.,
Park Tae Gwan
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800756
Subject(s) - hyaluronic acid , materials science , dispersity , nanocrystal , nanotechnology , adhesion , magnetite , surface modification , in vivo , aqueous solution , cancer therapy , chemical engineering , biophysics , cancer , polymer chemistry , organic chemistry , chemistry , metallurgy , composite material , biology , genetics , microbiology and biotechnology , engineering
Hyaluronic‐acid immobilized monodisperse magnetic nanocrystals (HA‐DN/MNCs) are synthesized. Dopamine, the analogue of 3,4‐dihydroxy‐ L ‐phenylalanine responsible for the adhesion properties in proteins excreted by mussels, plays a key role in the surface modification of nanocrystals. HA‐DN/MNCs exhibit great stability in aqueous solution, applicable for in vivo targeted‐cancer imaging.