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Multivalent, Saccharide‐Functionalized Gold Nanoparticles as Fully Synthetic Analogs of Type A Neisseria meningitidis Antigens
Author(s) -
Manea Flavio,
Bindoli Cristiano,
Fallarini Silvia,
Lombardi Grazia,
Polito Laura,
Lay Luigi,
Bonomi Renato,
Mancin Fabrizio,
Scrimin Paolo
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800737
Subject(s) - neisseria meningitidis , polyclonal antibodies , colloidal gold , antigen , neisseria , materials science , monolayer , bacteria , nanoparticle , polysaccharide , combinatorial chemistry , microbiology and biotechnology , nanotechnology , chemistry , biology , biochemistry , immunology , genetics
Antigen analogs of polyclonal antibodies specific for type A Neisseria mengitidis are prepared by covering gold clusters (2–5 nm in size) with a monolayer of saccharides that have the structure of the repeating unit of the capsular polysaccharide of this bacterium. These systems may find use as synthetic antigens for immunostimulation.