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In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy
Author(s) -
Tu HsiungLin,
Lin YuShen,
Lin HsiaYu,
Hung Yann,
Lo LeuWei,
Chen YangFang,
Mou ChungYuan
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800548
Subject(s) - photodynamic therapy , mesoporous silica , phototoxicity , hela , protoporphyrin ix , materials science , nanoparticle , nanotechnology , in vitro , nanomedicine , mesoporous material , chemistry , organic chemistry , biochemistry , catalysis
A versatile platform for photodynamic therapy (PDT) , mesoporous silica nanoparticles functionalized with protoporphyrin IX (PpIX‐MSNs), has been developed. In vitro studies on HeLa cells show high uptake efficiency. Phototoxicity results give both irradiation time‐ and dosage‐dependent cell death events. Because of the ease of incorporating other biomedical functional groups, we believe MSNs would be an ideal platform for biomedical applications.