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PEGylated Calcium Phosphate Nanocomposites as Smart Environment‐Sensitive Carriers for siRNA Delivery
Author(s) -
Zhang Mingzhen,
Ishii Atsushi,
Nishiyama Nobuhiro,
Matsumoto Satoru,
Ishii Takehiko,
Yamasaki Yuichi,
Kataoka Kazunori
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800448
Subject(s) - nanocomposite , nanocarriers , materials science , ethylene glycol , conjugate , nanotechnology , calcium , peg ratio , drug delivery , combinatorial chemistry , chemistry , organic chemistry , mathematical analysis , mathematics , finance , economics , metallurgy
A novel inorganic–organic hybrid nanocomposite is formed in situ using a simple and straightforward method. Conjugate of short interfering RNA (siRNA) duplex with poly(ethylene glycol) via a disulfide linkage (PEG–SS–siRNA) is demonstrated to regulate the crystal growth of calcium phosphate (CaP), yielding a monodispersed nanocomposite. The resultant nanocomposite can be utilized as nanocarriers for siRNA delivery.