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Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single‐Step Process
Author(s) -
Wang Wenxin,
Liang He,
Cheikh Al Ghanami Racha,
Hamilton Lloyd,
Fraylich Michael,
Shakesheff Kevin M.,
Saunders Brian,
Alexander Cameron
Publication year - 2009
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800382
Subject(s) - materials science , copolymer , biocompatible material , polymer , microparticle , nanotechnology , corona (planetary geology) , process (computing) , chemical engineering , polymer science , composite material , computer science , biomedical engineering , medicine , physics , astrobiology , venus , engineering , operating system
Surface‐engineered microparticles with a biodegradable polymer core and a programmable thermoresponsive biocompatible copolymer corona are produced. The particles form free‐flowing dispersions below 37 °C, but form porous space‐filling gels above this temperature, as a result of chain collapse of the copolymer corona. When particles are mixed with biological materials, they form encapsulating gels that can support cell growth.