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Ultrathin Coatings with Change in Reactivity over Time Enable Functional In Vitro Networks Of Insect Neurons
Author(s) -
Reska Anna,
Gasteier Peter,
Schulte Petra,
Moeller Martin,
Offenhäusser Andreas,
Groll Juergen
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800270
Subject(s) - gryllus bimaculatus , materials science , cricket , covalent bond , nanotechnology , biomolecule , adhesion , coating , insect , in vitro , biophysics , biology , organic chemistry , composite material , biochemistry , chemistry , botany , ecology
It's just not cricket! A novel coating system that enables covalent attachment of biomolecules in a nonfouling environment without use of additional chemical crosslinkers is presented. Concanavalin A is patterned on the coatings to direct cell adhesion and growth of neurons from the cricket Gryllus bimaculatus and generate functional, patterned in vitro insect neuronal networks for the first time.