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Ribosome Display and Dip‐Pen Nanolithography for the Fabrication of Protein Nanoarrays
Author(s) -
Kim Jung Dong,
Ahn DaeGyun,
Oh JongWon,
Park Woojun,
Jung Hyungil
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800027
Subject(s) - dip pen nanolithography , nanolithography , fabrication , materials science , nanotechnology , nanometre , translation (biology) , ribosome , messenger rna , rna , chemistry , gene , biochemistry , medicine , alternative medicine , pathology , composite material
Protein nanochip fabrication is performed via immobilizing proteins by dip‐pen nanolithography (DPN) and the ribosome display technique. Protein–ribosome–mRNA fusion molecules permit the simultaneous immobilization of functional proteins without purification through hybridization to complementary DNA that has been immobilized on a nanometer scale on the surface via DPN.