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Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging
Author(s) -
Park JiHo,
von Maltzahn Geoffrey,
Zhang Lianglin,
Schwartz Michael P.,
Ruoslahti Erkki,
Bhatia Sangeeta N.,
Sailor Michael J.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200800004
Subject(s) - in vivo , in vitro , conjugated system , materials science , nanoparticle , iron oxide nanoparticles , nanotechnology , iron oxide , dextran , homing (biology) , biophysics , chemistry , biochemistry , biology , polymer , ecology , microbiology and biotechnology , metallurgy , composite material
The synthesis, in vitro, and in vivo behavior of tumor‐homing magnetic nanoworms (NW) are described. The particles consist of a chainlike aggregation of iron oxide (IO) cores in a dextran coating. When conjugated with a tumor‐targeting peptide, they interact more effectively with a tumor‐based target in vitro relative to spherical nanoparticles. Untargeted NW display similar in vivo circulation times and enhanced passive accumulation in mouse xenograft tumors relative to untargeted spherical IO nanoparticles.