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Cell Nucleus Penetration by Quantum Dots Induced by Nuclear Staining Organic Fluorophore and UV‐Irradiation
Author(s) -
Xu Yang,
Wang Qiangbin,
He Ping,
Dong Qiaomei,
Liu Fang,
Liu Yan,
Lin Lin,
Yan Hao,
Zhao Xiaohang
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200703238
Subject(s) - fluorophore , quantum dot , materials science , nucleus , intracellular , penetration (warfare) , biophysics , cell , nanotechnology , nanoparticle , irradiation , cell nucleus , staining , optoelectronics , fluorescence , chemistry , physics , microbiology and biotechnology , optics , biochemistry , biology , nuclear physics , genetics , engineering , operations research
The behavior of quantum dots (QDs) in penetration into cell nuclei is investigated. It is discovered that the combination of an organic fluorophore staining the nuclei and UV irradiation can cause QDs of certain size or surface modifications to be trapped inside the cell nuclei. These findings not only provide new insights for intracellular transportation of nanoparticles but also create unique opportunities for labeling biological events inside cell nuclei.