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Label‐Free Colorimetric Detection of Lead Ions with a Nanomolar Detection Limit and Tunable Dynamic Range by using Gold Nanoparticles and DNAzyme
Author(s) -
Wang Zidong,
Lee Jung Heon,
Lu Yi
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200703181
Subject(s) - detection limit , deoxyribozyme , materials science , colloidal gold , nanoparticle , substrate (aquarium) , nanotechnology , selectivity , ion , analytical chemistry (journal) , catalysis , chromatography , chemistry , organic chemistry , oceanography , geology
In the presence of Pb 2+ , a cleaved enzyme–substrate complex releases ssDNA that adsorbs onto and stabilizes gold nanoparticles (AuNPs) against salt‐induced aggregation. In the absence of Pb 2+ , the uncleaved complex can not stabilize the AuNPs, resulting in purple–blue AuNP aggregates (see figure). The sensor has a low detection limit of 3 nM, a high selectivity, and a tunable dynamic range.