Premium
Interfacing Functionalized Carbon Nanohorns with Primary Phagocytic Cells
Author(s) -
Lacotte Stéphanie,
García Ainara,
Décossas Marion,
AlJamal Wafa' T.,
Li Shouping,
Kostarelos Kostas,
Muller Sylviane,
Prato Maurizio,
Dumortier Hélène,
Bianco Alberto
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200702753
Subject(s) - interfacing , immune system , adjuvant , carbon fibers , reactive oxygen species , immunopotentiator , primary (astronomy) , function (biology) , vaccine adjuvant , chemistry , computer science , immunology , nanotechnology , biology , microbiology and biotechnology , biochemistry , materials science , physics , astronomy , composite number , computer hardware , algorithm
Functionalized carbon nanohorns ( f ‐CNH ) are uptaken by macrophages, without affecting cell viability. f ‐CNH induce the production of reactive oxygen species and of pro‐inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f ‐CNH for drug delivery. However, it could be exploited as an intrinsic f ‐CNH adjuvant function for biomedical applications requiring some activation of the immune system.