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Monodisperse Chitosan Microspheres with Interesting Structures for Protein Drug Delivery
Author(s) -
Wei Wei,
Yuan Lan,
Hu Gang,
Wang LianYan,
Wu Jie,
Hu Xue,
Su ZhiGuo,
Ma GuangHui
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200702663
Subject(s) - dispersity , microsphere , chitosan , drug delivery , materials science , nanotechnology , porosity , chemical engineering , polymer chemistry , composite material , engineering
Monodisperse chitosan microspheres with different structures are prepared and loaded with proteins, as exemplified in the figure. The different types of microspheres show different protein release profiles, which implies that that their properties can be adjusted to fit the needs of different therapeutic applications. The structural properties of the microspheres are varied by adjusting the surface charge, cavity size, and wall porosity.