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Sequence‐Dependent Fluorescence of DNA‐Hosted Silver Nanoclusters
Author(s) -
Gwinn E. G.,
O'Neill P.,
Guerrero A. J.,
Bouwmeester D.,
Fygenson D. K.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200702380
Subject(s) - nanoclusters , dna , fluorescence , sequence (biology) , dna sequencing , nanotechnology , base pair , computational biology , biology , materials science , biophysics , biochemistry , physics , quantum mechanics
DNA‐bound silver nanoemitters reside in single‐stranded regions of the host DNA. Their fluorescence is sensitive to both the DNA base sequence and its secondary structure. Fluorescence from individual emitters hosted by DNA “hairpins”, which are suitable for incorporation into DNA scaffolds, is detectable using standard epifluorescence techniques.