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Dynamic Imaging of Functionalized Multi‐Walled Carbon Nanotube Systemic Circulation and Urinary Excretion
Author(s) -
Lacerda L.,
Soundararajan A.,
Singh R.,
Pastorin G.,
AlJamal K. T.,
Turton J.,
Frederik P.,
Herrero M. A.,
Li S.,
Bao A.,
Emfietzoglou D.,
Mather S.,
Phillips W. T.,
Prato M.,
Bianco A.,
Goins B.,
Kostarelos K.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200702334
Subject(s) - materials science , systemic circulation , carbon nanotube , nanotechnology , filtration (mathematics) , urinary system , biomedical engineering , medicine , statistics , mathematics
Intravenously administered multi‐walled carbon nanotubes, functionalized with DTPA and radiolabeled with Indium‐111, were dynamically tracked in vivo using a microSingle Photon Emission Tomography scanner. Imaging showed that nanotubes enter the systemic blood circulation and within 5 min begin to permeate through the renal glomerular filtration system into the bladder.