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Confinement‐Induced Enhancement of Antigen–Antibody Interactions within Binary Nanopatterns to Achieve Higher Efficiency of On‐Chip Immunosensors
Author(s) -
Krishnamoorthy Sivashankar,
Himmelhaus Michael
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200702188
Subject(s) - materials science , nanotechnology , chip , binary number , optoelectronics , computer science , telecommunications , arithmetic , mathematics
By combining molecular self‐assembly, nanosphere lithography and reactive ion etching , large‐scale nanopatterns of antibodies are fabricated for direct application in state‐of‐the‐art on‐chip immunosensors. Using in‐situ surface plasmon resonance, the patterns are studied in view of their antigen binding capacity, which shows an increase of up to 120% solely in the case of antibody confinement into the nanopatches by means of a nonfouling embedding matrix (see figure).