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Motor Protein CF 0 F 1 Reconstituted in Lipid‐Coated Hemoglobin Microcapsules for ATP Synthesis
Author(s) -
Qi W.,
Duan L.,
Wang K. W.,
Yan X. H.,
Cui Y.,
He Q.,
Li J.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200702155
Subject(s) - materials science , atp hydrolysis , hydrolysis , atpase , catalysis , drug delivery , atp synthase , proton , hemoglobin , chemical engineering , nanotechnology , enzyme , combinatorial chemistry , biochemistry , chemistry , physics , quantum mechanics , engineering
ATPase, the smallest molecular motor in nature, is assembled within lipid‐modified protein microcapsules. ATP is generated by driving the ATPase using a proton gradient provided by the oxidation and hydrolysis of glucose, as schematically illustrated in the figure. The demonstration of ATPase catalysis in microcapsules has implications for the design of functional “smart” materials and drug delivery vehicles.