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Matrices of Acidic β ‐Sheet Peptides as Templates for Calcium Phosphate Mineralization
Author(s) -
SegmanMagidovich Shlomit,
Grisaru Haviv,
Gitli Tamar,
LeviKalisman Yael,
Rapaport Hanna
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200702125
Subject(s) - apatite , amorphous calcium phosphate , nucleation , materials science , biomineralization , template , calcium , phosphate , supersaturation , aspartic acid , amphiphile , chemical engineering , mineralization (soil science) , monolayer , crystallography , nanotechnology , amino acid , copolymer , polymer , biochemistry , organic chemistry , chemistry , metallurgy , composite material , nitrogen , engineering
De novo designed amphiphilic and acidic β‐sheet peptides in the form of monolayers and fibril assemblies are used as templates for monitoring calcium phosphate nucleation. The regular arrangement of negatively charged aspartic acid residues in a solution supersaturated with respect to apatite induces the nucleation of amorphous calcium phosphate, which over time transforms into apatite (see figure). This study demonstrates the bottom‐to‐top design and synthesis of new mineralized‐peptide composite biomaterials.