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Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity
Author(s) -
Tong L.,
Zhao Y.,
Huff T. B.,
Hansen M. N.,
Wei A.,
Cheng J.X.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200701974
Subject(s) - nanorod , intracellular , membrane , materials science , cell membrane , conjugated system , biophysics , microbiology and biotechnology , nanotechnology , chemistry , biochemistry , biology , composite material , polymer
Folate‐conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near‐infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.