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Modulating Neuronal Responses by Controlled Integration of Acetylcholine‐like Functionalities in Biomimetic Polymers
Author(s) -
Gumera C. B.,
Wang Y.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200701747
Subject(s) - materials science , polymer , neurite , acetylcholine , nanotechnology , laminin , biochemistry , chemistry , biology , in vitro , cell , pharmacology , composite material
This paper describes a new pathway to neuroactive materials that relies on integration of neurotransmitter‐like functional groups into synthetic polymers. A series of biodegradable polymers are synthesized with varying concentrations of acetylcholine‐like functionalities (ALFs) using a modular design. The polymers with medium ALF contents resemble laminin in promoting neurite sprouting and extension while maintaining phenotypic protein expression of neurons.