Premium
Self‐Assembly of Cell–Microparticle Hybrids
Author(s) -
Krishnamachari Y.,
Pearce M. E.,
Salem A. K.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200701689
Subject(s) - microparticle , materials science , avidin , biotin , nanotechnology , surface modification , biophysics , chemical engineering , biochemistry , chemistry , biology , engineering
Synthetic‐biological hybrids of biodegradable microparticles and transfected cells are assembled, as schematically illustrated in the figure. The cells are surface‐functionalized with biotin and the particle surface is also engineered with biotin. Avidin is then used as a bridging protein to bind together the microparticles and the surface‐ functionalized cells.