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Direct Delivery and Submicrometer Patterning of DNA by a Nanofountain Probe
Author(s) -
Kim K.H.,
Sanedrin R. G.,
Ho A. M.,
Lee S. W.,
Moldovan N.,
Mirkin C. A.,
Espinosa H. D.
Publication year - 2008
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200701254
Subject(s) - materials science , nanotechnology , substrate (aquarium) , dna , nanoparticle , biology , genetics , ecology
Biomolecular patterning is achieved using a nanofountain probe (NFP) that delivers a liquid solution of DNA through a volcano‐like aperture to a substrate (see figure). Spot features as small as 200 nm in diameter can be routinely made at room temperature over a wide humidity range. Gold nanoparticles functionalized with sequences complementary to the patterned DNA demonstrate that biological activity is retained by the deposited features.