Ultrathin Multilayered Films Assembled from “Charge‐Shifting” Cationic Polymers: Extended, Long‐Term Release of Plasmid DNA from Surfaces | Zendy

Zhang J. | Zendy; Lynn D. M. | Zendy

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Ultrathin Multilayered Films Assembled from “Charge‐Shifting” Cationic Polymers: Extended, Long‐Term Release of Plasmid DNA from Surfaces

Author(s) -

Zhang J.,

Lynn D. M.

Publication year - 2007

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200701028

Subject(s) - cationic polymerization , polymer , fabrication , materials science , dna , hydrolysis , side chain , nanotechnology , polyelectrolyte , chemical engineering , polymer chemistry , organic chemistry , chemistry , biochemistry , composite material , medicine , alternative medicine , pathology , engineering

Ultrathin multilayered films can be designed to release plasmid DNA for three months by using side‐chain functionalized ‘charge‐shifting' cationic polymers. Slow hydrolysis of the side chains of these polymers facilitates film disruption and release of DNA over periods longer than films fabricated using degradable cationic polymers, and suggests approaches to the fabrication of thin films for the localized and long‐term release of DNA, proteins, or other agents from surfaces.

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