Premium
Biomimetic pH Sensitive Polymersomes for Efficient DNA Encapsulation and Delivery
Author(s) -
Lomas H.,
Canton I.,
MacNeil S.,
Du J.,
Armes S. P.,
Ryan A. J.,
Lewis A. L.,
Battaglia G.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200700941
Subject(s) - polymersome , vesicle , amphiphile , copolymer , gene delivery , nanotechnology , dna , materials science , polymer , transfection , biophysics , membrane , chemistry , biochemistry , gene , biology , composite material
A novel gene delivery vector based on the ability of a synthetic amphiphilic block copolymer to mimic biological phospholipids by forming membrane‐enclosed structures, specifically nanometer‐sized vesicles, is presented. A pH‐sensitive diblock copolymer forms vesicles (polymersomes) at neutral pH, and dissolves completely as unimers at endocytic pH (see figure). GFP‐encoding plasmid DNA are successfully encapsulated inside the polymer vesicles, and delivered intracellularly.