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Remotely Triggered Release from Magnetic Nanoparticles
Author(s) -
Derfus A. M.,
von Maltzahn G.,
Harris T. J.,
Duza T.,
Vecchio K. S.,
Ruoslahti E.,
Bhatia S. N.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200700091
Subject(s) - superparamagnetism , materials science , nanoparticle , magnetic nanoparticles , nanotechnology , in vivo , magnetization , magnetic field , physics , microbiology and biotechnology , quantum mechanics , biology
Multifunctional nanoparticles are multivalent, remotely‐actuated, and imaged non‐invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat‐labile tethers to release model drugs in vivo (see figure).