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Endothelialization of Titanium Surfaces
Author(s) -
Meyers S. R.,
Hamilton P. T.,
Walsh E. B.,
Kenan D. J.,
Grinstaff M. W.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200700029
Subject(s) - peptide , phage display , coating , materials science , titanium , adhesion , motif (music) , nanotechnology , binding affinities , cell adhesion , biophysics , combinatorial chemistry , biochemistry , chemistry , biology , receptor , physics , composite material , metallurgy , acoustics
An interfacial peptide coating possessing domains that bind to Ti and endothelial cells is synthesized (see figure). Peptides with specific adherence to Ti are identified using phage display, and the RGD motif was selected for cell binding. The peptide can be applied from aqueous solution and possesses micromolar binding affinities. The coating significantly enhances endothelial cell adhesion and spreading under both static and dynamic conditions.