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Length‐Dependent Uptake of DNA‐Wrapped Single‐Walled Carbon Nanotubes
Author(s) -
Becker M. L.,
Fagan J. A.,
Gallant N. D.,
Bauer B. J.,
Bajpai V.,
Hobbie E. K.,
Lacerda S. H.,
Migler K. B.,
Jakupciak J. P.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200602667
Subject(s) - carbon nanotube , materials science , dna , fluorescence , nanotechnology , biophysics , carbon fibers , cell , cover (algebra) , chemical engineering , crystallography , composite material , optics , biochemistry , biology , chemistry , mechanical engineering , physics , engineering , composite number
A length threshold for cell uptake of DNA‐wrapped single‐walled carbon nanotubes (SWNTs) by human lung fibroblasts (IMR90) is identified. Competitive uptake experiments with well‐defined and characterized length fractions show that SWNTs above the length threshold are excluded from the cell, whereas SWNTs labeled with Cy3‐derivatized DNA below the threshold are able to access the cell interior, as shown in the fluorescence image and on the cover.