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Dynamically Restructuring Hydrogel Networks Formed with Reversible Covalent Crosslinks
Author(s) -
Roberts M. C.,
Hanson M. C.,
Massey A. P.,
Karren E. A.,
Kiser P. F.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200602649
Subject(s) - covalent bond , phenylboronic acid , salicylhydroxamic acid , polymer , nanotechnology , materials science , drug delivery , restructuring , combinatorial chemistry , chemistry , organic chemistry , catalysis , finance , economics , composite material , enzyme
Dynamically restructuring hydrogel networks are formed from two water‐soluble polymers by functionalization with phenylboronic acid (PBA) and salicylhydroxamic acid (SHA) moieties that interact through pH‐sensitive and reversible covalent crosslinks (see figure). The networks can be tuned to display a wide range of pH‐responsive properties, which can potentially be exploited for drug delivery systems in biological environments where similar acidic changes occur.