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Universal Gradient Substrates for “Click” Biofunctionalization
Author(s) -
Gallant N. D.,
Lavery K. A.,
Amis E. J.,
Becker M. L.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200602221
Subject(s) - biomolecule , template , click chemistry , materials science , nanotechnology , fabrication , adhesion , glycine , combinatorial chemistry , chemistry , biochemistry , polymer chemistry , amino acid , medicine , alternative medicine , pathology , composite material
Versatile templates for gradient immobilization of biomolecules by click chemistry are easily generated from reproducible and tunable surface energy gradients. An arginine–glycine–aspartate (RGD) peptide density gradient controls cell adhesion (see figure), and demonstrates the utility of this fabrication process for making substrates that can screen cell response to bioactive materials.