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Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell‐Adhesive Peptides
Author(s) -
Raynor J. E.,
Petrie T. A.,
García A. J.,
Collard D. M.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200602129
Subject(s) - ethylene glycol , methacrylate , materials science , surface modification , polymer chemistry , polymer brush , adhesion , titanium , polymer , polymerization , monolayer , methyl methacrylate , adhesive , polymer science , chemical engineering , nanotechnology , chemistry , organic chemistry , layer (electronics) , composite material , engineering , metallurgy
A monolayer of 11‐(2‐bromo‐2‐methyl)propionyloxy)undecenyldimethylchlorosilane on titanium serves as an initiator for surface‐initiated atom‐transfer polymerization of (oligoethylene glycol) methacrylate (OEGMA) to prepare poly(OEGMA) brushes. The polymer brush affords resistance to adhesion of osteoblastic cells. Treatment of the brush‐modified surface with 4‐nitrophenyl chloroformate followed by a GFOGER‐containing peptide promotes cell adhesion, thereby representing a strategy to impart biofunctionality to titanium (see figure) and thereby promote osseointegration.