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Gold Nanoparticles Inhibit the Proliferation of Multiple Myeloma Cells
Author(s) -
Bhattacharya R.,
Patra C. R.,
Verma R.,
Kumar S.,
Greipp P. R.,
Mukherjee P.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200602098
Subject(s) - colloidal gold , cell cycle , materials science , peripheral blood mononuclear cell , microbiology and biotechnology , nanoparticle , cell growth , multiple myeloma , biophysics , cell , cancer research , in vitro , nanotechnology , biology , biochemistry , immunology
Gold nanoparticles significantly inhibit proliferation in multiple myeloma cell lines (see figure) in a dose‐dependent manner. Gold‐treated multiple myeloma cells show cell‐cycle arrest in the G1‐phase (the phase when chromosomes prepare for replication) by up‐regulation of cell‐cycle cyclin‐dependent kinase inhibitor proteins p21 and p27. Gold nanoparticles do not affect normal peripheral blood mononuclear cells.