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Thermo and pH Dual‐Responsive Nanoparticles for Anti‐Cancer Drug Delivery
Author(s) -
Zhang L.,
Guo R.,
Yang M.,
Jiang X.,
Liu B.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200601817
Subject(s) - copolymer , polycaprolactone , nanoparticle , materials science , drug delivery , paclitaxel , acrylic acid , drug , block (permutation group theory) , nanotechnology , polymer , chemical engineering , cancer , pharmacology , medicine , geometry , mathematics , engineering , composite material
Thermo and pH dual‐responsive nanoparticles encapsulating an anti‐cancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N‐isopropylacrylamide‐ co ‐acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor‐targeted anti‐caner drug delivery.