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Enzyme‐Responsive Polymer Hydrogel Particles for Controlled Release
Author(s) -
Thornton P. D.,
Mart R. J.,
Ulijn R. V.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200601784
Subject(s) - materials science , polymer , self healing hydrogels , swelling , macromolecule , enzyme , controlled release , nanotechnology , immobilized enzyme , chemical engineering , polymer science , polymer chemistry , composite material , organic chemistry , chemistry , biochemistry , engineering
A conceptually new approach to polymer‐based enzyme‐triggered release is described, whereby the selective catalytic action of (disease‐specific) enzymes triggers a charge‐induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).