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Bone Formation Mediated by Synergy‐Acting Growth Factors Embedded in a Polyelectrolyte Multilayer Film
Author(s) -
Dierich A.,
Le Guen E.,
Messaddeq N.,
Stoltz J.F.,
Netter P.,
Schaaf P.,
Voegel J.C.,
BenkiraneJessel N.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200601271
Subject(s) - polyelectrolyte , bone formation , materials science , chemistry , medicine , composite material , polymer , endocrinology
A bifunctionalized polyelectrolyte multilayer film (PEM film) that can drive embryonic stem cells to cartilage or bone differentiation is presented. A model system is constructed from a PEM film into which transforming growth factor β 1 and bone morphogenetic protein has been embedded. The synergy between both factors is required for the film to be bioactive. Osteogenesis in embryonic stem cells is induced by the film (see figure).