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Combining Fluorescent Probes and Biofunctional Magnetic Nanoparticles for Rapid Detection of Bacteria in Human Blood
Author(s) -
Gao J.,
Li L.,
Ho P.L.,
Mak G. C.,
Gu H.,
Xu B.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200601058
Subject(s) - bacteria , vancomycin , fluorescence , materials science , nanoparticle , human blood , magnetic nanoparticles , conjugated system , amine gas treating , fluorescent labelling , fluorescein , nanotechnology , polymer , chemistry , staphylococcus aureus , organic chemistry , biology , physiology , genetics , physics , composite material , quantum mechanics
Detection of bacteria in human blood within two hours is achieved through the use of vancomycin‐functionalized FePt nanoparticles in combination with a vancomycin‐conjugated fluorescent probe, as shown in the figure (B: bacteria; Van: vancomycin; FLA: fluorescein amine). This promises to be a sensitive and rapid protocol for detecting bacteria in blood products or other targets in biological samples.