Temperature‐Controlled Assembly and Release from Polymer Vesicles of Poly(ethylene oxide)‐ block ‐ poly( N ‐isopropylacrylamide) | Zendy

Qin S. | Zendy; Geng Y. | Zendy; Discher D. E. | Zendy; Yang S. | Zendy

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Temperature‐Controlled Assembly and Release from Polymer Vesicles of Poly(ethylene oxide)‐ block ‐ poly( N ‐isopropylacrylamide)

Author(s) -

Qin S.,

Geng Y.,

Discher D. E.,

Yang S.

Publication year - 2006

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200601019

Subject(s) - poly(n isopropylacrylamide) , vesicle , ethylene oxide , materials science , copolymer , dispersity , poly ethylene , lower critical solution temperature , polymer , polymer chemistry , membrane , oxide , chemical engineering , nanotechnology , ethylene , chemistry , organic chemistry , biochemistry , catalysis , engineering , composite material , metallurgy

Narrow‐dispersity thermoresponsive block copolymers of poly(ethylene oxide)‐ block ‐poly( N ‐isopropylacrylamide) self‐assemble into vesicles at temperatures above 32 °C. The vesicles integrate a hydrophobic fluorescent dye into their membranes and encapsulate the hydrophilic anticancer drug doxorubicin. Temperature‐controlled release of the dye through disintegration of the vesicles takes place at temperatures below 32 °C, as shown in the figure.

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