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Composite Nanocapsules: Lipid Vesicles Covered with Several Layers of Crosslinked Polyelectrolytes
Author(s) -
Germain M.,
Grube S.,
Carriere V.,
RichardFoy H.,
Winterhalter M.,
Fournier D.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200600860
Subject(s) - polyelectrolyte , nanoreactor , nanocapsules , materials science , composite number , nanotechnology , layer by layer , substrate (aquarium) , template , chemical engineering , vesicle , layer (electronics) , polymer , nanoparticle , membrane , chemistry , composite material , oceanography , geology , biochemistry , engineering
Biologically active proteins are loaded into liposomes , which are then used as templates for the layer‐by‐layer deposition of polyelectrolytes. The multilayer polyelectrolyte layers are then crosslinked to form a robust protective barrier (see figure). Enzymes encapsulated within composite nanocapsules generated by this procedure are able to retain their substrate selectivity and activity even in the presence of detergent, suggesting the potential use of these structures as nanoreactors.