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Targeting and Uptake of Multilayered Particles to Colorectal Cancer Cells
Author(s) -
Cortez C.,
TomaskovicCrook E.,
Johnston A. P. R.,
Radt B.,
Cody S. H.,
Scott A. M.,
Nice E. C.,
Heath J. K.,
Caruso F.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200600564
Subject(s) - internalization , monoclonal antibody , colorectal cancer , cancer , cancer research , nanotechnology , materials science , antibody , cell , medicine , chemistry , immunology , biochemistry
Core/shell particles and capsules formed by a layer‐by‐layer technique are biofunctionalized with a humanized A33 monoclonal antibody (huA33 mAb) that binds to the A33 antigen present on colorectal cancer cells (see figure). Targeting to a colorectal cancer cell line shows selective binding and internalization of particles.