Targeting and Uptake of Multilayered Particles to Colorectal Cancer Cells | Zendy

Cortez C. | Zendy; TomaskovicCrook E. | Zendy; Johnston A. P. R. | Zendy; Radt B. | Zendy; Cody S. H. | Zendy; Scott A. M. | Zendy; Nice E. C. | Zendy; Heath J. K. | Zendy; Caruso F. | Zendy

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Targeting and Uptake of Multilayered Particles to Colorectal Cancer Cells

Author(s) -

Cortez C.,

TomaskovicCrook E.,

Johnston A. P. R.,

Radt B.,

Cody S. H.,

Scott A. M.,

Nice E. C.,

Heath J. K.,

Caruso F.

Publication year - 2006

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200600564

Subject(s) - internalization , monoclonal antibody , colorectal cancer , cancer , cancer research , nanotechnology , materials science , antibody , cell , medicine , chemistry , immunology , biochemistry

Core/shell particles and capsules formed by a layer‐by‐layer technique are biofunctionalized with a humanized A33 monoclonal antibody (huA33 mAb) that binds to the A33 antigen present on colorectal cancer cells (see figure). Targeting to a colorectal cancer cell line shows selective binding and internalization of particles.

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