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Ultrasound‐Triggered Smart Drug Release from a Poly(dimethylsiloxane)– Mesoporous Silica Composite
Author(s) -
Kim H.J.,
Matsuda H.,
Zhou H.,
Honma I.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200600387
Subject(s) - mesoporous silica , drug delivery , materials science , ibuprofen , drug , composite number , mesoporous material , nanotechnology , in vivo , ultrasound , biomedical engineering , chemical engineering , organic chemistry , composite material , radiology , pharmacology , chemistry , medicine , microbiology and biotechnology , engineering , biology , catalysis
Ultrasound is used as an external trigger for the pulsatile release of the drug ibuprofen. The system is composed of mesoporous silica as the drug reservoir and poly(dimethylsiloxane) (PDMS) as an implantable body. This system could find use for in vivo delivery of drugs in response to changes in physiological conditions.