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Preparation of Biocompatible Magnetite Nanocrystals for In Vivo Magnetic Resonance Detection of Cancer
Author(s) -
Hu F. Q.,
Wei L.,
Zhou Z.,
Ran Y. L.,
Li Z.,
Gao M. Y.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200600385
Subject(s) - biocompatible material , nanocrystal , magnetite , materials science , magnetic resonance imaging , nanotechnology , in vivo , cancer , biomedical engineering , medicine , biology , radiology , microbiology and biotechnology , metallurgy
Biocompatible Fe 3 O 4 magnetic nanocrystals with reactive moieties on the surface can be prepared via a “one‐pot” reaction and used straightforwardly in cancer detection by being coupled with a specific cancer‐targeting antibody. It is demonstrated that the as‐prepared Fe 3 O 4 nanocrystals can potentially be used as effective magnetic resonance imaging (MRI) contrast agents for cancer diagnosis (see figure).