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Nano‐ to Microscale Porous Silicon as a Cell Interface for Bone‐Tissue Engineering
Author(s) -
Sun W.,
Puzas J. E.,
Sheu T.J.,
Liu X.,
Fauchet P. M.
Publication year - 2007
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200600319
Subject(s) - materials science , microscale chemistry , biomaterial , porosity , tissue engineering , nanotechnology , porous silicon , drug delivery , nano , osteoblast , silicon , biomedical engineering , composite material , metallurgy , chemistry , mathematics education , mathematics , medicine , biochemistry , in vitro
Porous Si (PSi) is shown to support and promote primary osteoblast growth (shown in the figure), protein‐matrix synthesis, and mineralization. It is also shown that the osteoconductivity of PSi and other cellular responses can be controlled by altering the micro‐/ nanoarchitecture of the porous interface. This material has the potential to be a functional biomaterial with both osteoconductivity and drug‐ delivery functions.