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Synthesis and Peptide‐Induced Degradation of Biocompatible Fibers Based on Highly Branched Poly(2‐hydroxyethyl methacrylate)
Author(s) -
Wang L.,
Li C.,
Ryan A. J.,
Armes S. P.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200600314
Subject(s) - copolymer , materials science , methacrylate , biocompatible material , polymer chemistry , degradation (telecommunications) , dissolution , electrospinning , disulfide bond , chemical engineering , polymer , composite material , chemistry , medicine , telecommunications , computer science , biomedical engineering , engineering , biochemistry
Biocompatible fibers (see figure) are prepared by electrospinning branched poly(2‐hydroxyethyl methacrylate) copolymers from methanol. These copolymers contain disulfide branch sites that can be cleaved using tripeptides such as glutathione. Cleavage reduces the copolymer molecular weight substantially, leading to complete fiber dissolution.