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Modulating Expanded Polytetrafluoroethylene Vascular Graft Host Response via Citric Acid‐Based Biodegradable Elastomers
Author(s) -
Yang J.,
Motlagh D.,
Allen J. B.,
Webb A. R.,
Kibbe M. R.,
Aalami O.,
Kapadia M.,
Carroll T. J.,
Ameer G. A.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200600230
Subject(s) - thrombogenicity , materials science , polytetrafluoroethylene , polyester , elastomer , biomedical engineering , citric acid , biocompatible material , polymer chemistry , composite material , surgery , chemistry , organic chemistry , medicine , thrombosis
A biodegradable polyester elastomer, poly(1,8‐octanediol citrate) (POC), is used to modify the lumen of expanded polytetrafluoroethylene (ePTFE) grafts via a spin‐shearing method followed by interfacial in situ polycondensation. We demonstrate successful surface modification of ePTFE grafts without affecting graft compliance (see figure). The POC interface confers hydrophilicity, reduced thrombogenicity, facilitated graft endothelialization in vitro, and reduced macrophage infiltration on the ePTFE grafts.