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Using a Core–Sheath Distribution of Surface Chemistry through 3D Tissue Engineering Scaffolds to Control Cell Ingress
Author(s) -
Barry J. J. A.,
Howard D.,
Shakesheff K. M.,
Howdle S. M.,
Alexander M. R.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200502719
Subject(s) - materials science , tissue engineering , core (optical fiber) , nanotechnology , surface (topology) , surface modification , surface engineering , chemical engineering , biomedical engineering , composite material , engineering , geometry , mathematics
A core/sheath distribution of cell‐adhesive and non‐cell‐adhesive surface coatings is produced in porous biodegradable poly( D , L ‐lactic acid) discs using sequential plasma polymerization. The figure and cover show an X‐ray micro‐computed tomography image of a section of a 10 mm diameter, 4 mm thick scaffold where fibroblast cells (shown in red) have been encouraged by the surface chemistry to penetrate to the scaffold core.