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Covalent Attachment of Low Molecular Weight Poly(ethylene imine) Improves Tat Peptide Mediated Gene Delivery
Author(s) -
Alexis F.,
Lo S.L.,
Wang S.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200502173
Subject(s) - covalent bond , imine , materials science , peptide , gene delivery , ethylene , nanotechnology , combinatorial chemistry , polymer chemistry , organic chemistry , biochemistry , gene , biology , chemistry , genetic enhancement , catalysis
A polymer‐peptide hybrid biomaterial synthesized by coupling poly(ethylene imine) directly to resin‐supported Tat peptide takes advantage of the unique features associated with the two original cationic materials and functions as a novel gene‐delivery vector with good biocompatibility. The figure shows cells transfected with green fluorescent protein (GFP) using complexes of the polymer‐peptide hybrid and GFP (scale bar: 100 μm).