Covalent Attachment of Low Molecular Weight Poly(ethylene imine) Improves Tat Peptide Mediated Gene Delivery | Zendy

Alexis F. | Zendy; Lo S.L. | Zendy; Wang S. | Zendy

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Covalent Attachment of Low Molecular Weight Poly(ethylene imine) Improves Tat Peptide Mediated Gene Delivery

Author(s) -

Alexis F.,

Lo S.L.,

Wang S.

Publication year - 2006

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200502173

Subject(s) - covalent bond , imine , materials science , peptide , gene delivery , ethylene , nanotechnology , combinatorial chemistry , polymer chemistry , organic chemistry , biochemistry , gene , biology , chemistry , genetic enhancement , catalysis

A polymer‐peptide hybrid biomaterial synthesized by coupling poly(ethylene imine) directly to resin‐supported Tat peptide takes advantage of the unique features associated with the two original cationic materials and functions as a novel gene‐delivery vector with good biocompatibility. The figure shows cells transfected with green fluorescent protein (GFP) using complexes of the polymer‐peptide hybrid and GFP (scale bar: 100 μm).

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