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A Micropatterned Hydrogel Platform for Chemical Synthesis and Biological Analysis
Author(s) -
Zourob M.,
Gough J. E.,
Ulijn R. V.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200501840
Subject(s) - micropatterning , materials science , self healing hydrogels , nanotechnology , peptide , peptide synthesis , in situ , polymer , polymer chemistry , organic chemistry , chemistry , biochemistry , composite material
A polymer hydrogel platform for peptide arrays compatible both with solid‐phase peptide synthesis (SPPS) conditions and the aqueous environment essential for biological assays is demonstrated. Micropatterning followed by multiple‐step peptide synthesis in situ is followed by proof‐of‐concept on‐chip biological assays involving cells and enzymes (see Figure and cover).