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Nanostructured Hydrogels for Three‐Dimensional Cell Culture Through Self‐Assembly of Fluorenylmethoxycarbonyl–Dipeptides
Author(s) -
Jayawarna V.,
Ali M.,
Jowitt T. A.,
Miller A. F.,
Saiani A.,
Gough J. E.,
Ulijn R. V.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200501522
Subject(s) - self healing hydrogels , peptide , materials science , amphiphile , self assembly , self assembling peptide , dipeptide , tissue engineering , sequence (biology) , nanofiber , nanotechnology , amino acid , peptide sequence , combinatorial chemistry , polymer chemistry , copolymer , polymer , biomedical engineering , composite material , biochemistry , chemistry , medicine , gene
A number of short peptide amphiphiles consisting of dipeptides linked to fluorenylmethoxycarbonyl spontaneously form fibrous hydrogels under physiological conditions (see figure). The structural and physical properties of these gels are dictated by the amino acid sequence of the peptide building blocks, and the gels support the three‐dimensional cell culture of chondrocytes.