Premium
Electrically Controlled Drug Delivery from Biotin‐Doped Conductive Polypyrrole
Author(s) -
George P. M.,
LaVan D. A.,
Burdick J. A.,
Chen C.Y.,
Liang E.,
Langer R.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200501242
Subject(s) - polypyrrole , materials science , conductive polymer , drug delivery , linker , electrical conductor , nanotechnology , polymer , substrate (aquarium) , streptavidin , doping , chemical engineering , biotin , optoelectronics , composite material , chemistry , polymerization , biochemistry , oceanography , geology , computer science , engineering , operating system
A platform for controlled drug delivery using a conductive‐polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an applied potential can trigger release of the drug from the polymer surface (see figure).